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Awarded Trial: BPN-5

Grant ID

BPN-5

Illness

Bipolar Disorder

Primary Drug/Intervention

Topiramate

Primary Dosage

25-600 mg

Secondary Drug Intervention

Sibutramine

Secondary Dosage

5-15 mg

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

McElroy

Sample Size

60

Duration of Study Period for Each Subject

24 weeks

Outcome Measurements

N/A

Results

Forty six patients with bipolar disorder, who had also experienced significant weight gain (>10 pounds since intiation of current psychotropic regimen and a BMI > 30 kg/m2) were randomized to receive adjunctive topiramate or sibutramine for 26 weeks. Subjects receiving topiramate discontinued more often than those receiving sibutramine, but patients receiving topiramate experienced improvements in YMRS and IDS-C scores. Both drugs were associated with significant weight loss.

Publication

McElroy SL, Frye MA, Altshuler LL, Suppes T, Hellemann G, Black D, Mintz J, Kupka R, Nolen W, Leverich GS, Denicoff KD, Post RM, Keck PE Jr. A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorder. Bipolar Disorders 9:426-434, 2007.

Link

http://www.ncbi.nlm.nih.gov/pubmed/17547588

PI Name

Susan McElroy

Degree

MD

Center

N/A

Institution

University of Cincinnati College of Medicine

Address

231 Albert Sabin Way

City or Town

Cincinnati

State or Province

OH

Zip or Postal Code

45267

Country

USA

Email Address

MCELROSL@UCMAIL.UC.EDU