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Awarded Trial: 99-084
Repeated Transcranial Magnetic Stimulation (rTMS)
3 Hz and 10 Hz
Secondary Drug Intervention
Duration of Study Period for Each Subject
2 weeks / 10 daily sessions
HDRS, BDI, CGI
Fifty nine patients with major depression were randomized to receive: 1) left (n=12) or right (n=12) 3Hz rTMS with placebo medication; 2) left (n=10) or right (n=9) 10 Hz rTMS with placebo medication or 3) chlomipramine with sham rTMS (n=16). rTMS was administered to the prefrontal cortex daily for two weeks. There was no significant difference between groups with regard to Hamilton Depression Scores. There was a significantly higher proportion (55%) of treatment responders (reduction of Hamilton score by 50% or more) in the left 3Hz rTMS group. This treatment modality was also better tolerated and was associated with fewer dropouts.
Chistyakov AV, Kaplan B, Rubichek O, Kreinin I, Koren D, Feinsod M, Klein E. Antidepressant effects of different schedules of repetitive transcranial magnetic stimulation vs. chlomipramine in patients with major depression: relationship in changes in cortical excitability. Int J Neuropsychopharmacol. 2005 Jun;8(2):223-33.
Department of Psychiatry
Rambam Medical Center
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