Awarded Trial: 98-RC-325B-1
up to 2 mg/day
Secondary Drug Intervention
up to 10 mg/day
Duration of Study Period for Each Subject
Thirty-one children, aged 4-6 years, were treated with olazapine or risperidone for bipolar disoder. Both drugs improved YMRS scores to a similar degree. Olazapine treatment was associated with a slower rate of improvement, a greater degree of weight gain, and a higher drop-out rate.
Biederman J, Mick E, Hammerness P, Harpold T, Aleardi M, Dougherty M, Wozniak J. Open-label, 8-week trial of olazapine and risperidone for the treatment of bipolar disoder in preschool-age children. Biol Psychiatry 58: 589-594, 2005.
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