Awarded Trial: 98-RC-325A-1
Secondary Drug Intervention
Duration of Study Period for Each Subject
YMRS, HAM-D, BPRS
Twelve subjects with treatment-resistant mania were enrolled and eleven subjects were included in the data analysis. No subjects in the donepezil group and 60% of patients in the placebo group met response criteria of > 30% reduction in YMRS. There were no differences between groups on the HAM-D or BPRS.
Eden Evins A, Demopulos C, Nierenberg A, Culhane MA, Eisner L, Sachs G. A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania. Bipolar Disorders. 8:75-80, 2006.
Massachusetts General Hospital
50 Staniford St, 10th floor, Suite 1001
City or Town
State or Province
Zip or Postal Code