Back to Awarded Treatment Trials


Awarded Trial: 98-RC-325A-2

Grant ID

98-RC-325A-2

Illness

Bipolar Depression

Primary Drug/Intervention

Inositol

Primary Dosage

6-20 gm/day

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Sachs

Sample Size

17

Duration of Study Period for Each Subject

6 weeks with 8-week open label extension

Outcome Measurements

HAM-D

Results

Seventeen patients on therapeutic doses of lithium or valproic acid participated. Four of nine subjects on inositol and zero of eight on placebo were responders (> 50% reduction in HAM-D). These results did not reach statistical significance.

Publication

Eden Evins A, Demopulos C, Yovel I, Culhane M, Ogutha J, Grandin LD, Nierenberg AA, Sachs GS. Inositol augmentation of lithium or valproate for bipolar depression. Bipolar Disorders 2006;8:168-174.

Link

http://www.ncbi.nlm.nih.gov/pubmed/16542187

PI Name

Gary Sachs

Degree

MD

Center

Harvard Bipolar Research Program

Institution

Massachusetts General Hospital

Address

50 Staniford St, 5th Floor

City or Town

Boston

State or Province

MA

Zip or Postal Code

2114

Country

USA

Email Address

SachsG@aol.com