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Awarded Trial: 98-RC-325A-1

Grant ID

98-RC-325A-1

Illness

Bipolar Disorder

Primary Drug/Intervention

Donepezil

Primary Dosage

5-10 mg

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Sachs

Sample Size

23

Duration of Study Period for Each Subject

6 weeks

Outcome Measurements

YMRS, HAM-D, BPRS

Results

Twelve subjects with treatment-resistant mania were enrolled and eleven subjects were included in the data analysis. No subjects in the donepezil group and 60% of patients in the placebo group met response criteria of > 30% reduction in YMRS. There were no differences between groups on the HAM-D or BPRS.

Publication

Eden Evins A, Demopulos C, Nierenberg A, Culhane MA, Eisner L, Sachs G. A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania. Bipolar Disorders. 8:75-80, 2006.

Link

http://www.ncbi.nlm.nih.gov/pubmed/16411983

PI Name

Gary Sachs

Degree

MD

Center

Research Management

Institution

Massachusetts General Hospital

Address

50 Staniford St, 10th floor, Suite 1001

City or Town

Boston

State or Province

MA

Zip or Postal Code

2114

Country

USA

Email Address

sachsg@aol.com