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Awarded Trial: 98-156
Repeated Transcranial Magnetic Stimulation (rTMS)
5 Hz, 8 sec on, 22 sec off over 20 min
Secondary Drug Intervention
Duration of Study Period for Each Subject
Twenty three patients with bipolar depression were randomized to receive daily left prefrontal rTMS or placebo for 2 weeks. There were 12 patients with bipolar I depression, 9 patients with bipolar II depression and 2 patients with a mixed state. There was no significant difference between the rTMS group and the placebo group for number of antidepressant responders or for score on the Hamilton Depression Scale.
Nahas Z, Kozel FA, Li X, Anderson B, George MS. Left prefrontal TMS treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy. Bipolar Disorders 5:40-47, 2003.
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