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Awarded Trial: 97-RC-299-1
Secondary Drug Intervention
Duration of Study Period for Each Subject
Sixteen normal control subjects received s-adenosyl methionine (up to 1600 mg per day) for four weeks. Treatment was not associated with increased serum levels of toxic methylated compounds such as methanol, formic acid, or formaldehyde. Homocysteine levels were also measured and did not increase with treatment. Treatment was generally well-tolerated, although one patient experienced a mixed manic mood episode.
Gören JL, Stoll AL, Damico KE, Sarmiento IA, Cohen BM. Bioavailability and lack of toxicity of S-Adenosyl-L-methioine (SAMe) in humans. Pharmacotherapy. 24 (1): 1501-1507, 2004.
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