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Awarded Trial: 10T-1336

Grant ID

10T-1336

Illness

Schizophrenia

Primary Drug/Intervention

Simvastatin

Primary Dosage

40 mg/day

Secondary Drug Intervention

Ondansetron

Secondary Dosage

8 mg/day

Other Drug/Intervention

Hypercholesterolemia

Other Dosage

10-80 mg/day

Status

Completed

Investigator

Chaudhry

Sample Size

216

Duration of Study Period for Each Subject

6 months

Outcome Measurements

N/A

Results

This 2x2 study in Karachi, Pakistan, recruited 302 schizhoprenic patients, stabilized on anti-psychotic medication. Seventy-eight patients were randomized to add-on simvastatin and ondansetron, 73 to ondansetron, 76 to simvastatin and 74 to placebo. No significant changes in PANSS negative, positive and total scores were observed.

Publication

N/A

Link

N/A

PI Name

Imran Chaudhry

Degree

MD

Center

Department of Psychiatry

Institution

University of Manchester

Address

Lanchashire Care Early Intervention Service, G907, Stopford Building

City or Town

Oxford Road

State or Province

Manchester

Zip or Postal Code

M13 9PT

Country

United Kingdom

Email Address

ibchaudhry@btinternet.com