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Awarded Trial: 08TGF-1193
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, HAM-D, MATRICS Battery SANS
92 patients with a diagnosis of schizophrenia or schizoaffective psychosis being treated with antipsychotic medication, and who were cigarette smokers, were randomized to receive 2mg/day varenicline or placebo for 8 weeks. The study was designed to measure the effects of varenicline on measures of smoking, cognition, psychopathology and side effects. Although varenicline significantly reduced smoking in schizophrenic patients, there were no differences in cognitive function, psychopathology scores or side-effects.
Research Foundation for Mental Hygiene, Inc.
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