Awarded Trial: 07TGS-1051
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, Simpson-Angus, CPT, the Digits Forward and Backward, the Visuospatial Memory Task, and the Wisconsin Card Sorting Test, MNWS, QSU-Brief, mCEO, SANS, DAI
Randomized 120 patients to varenicline, a nicotinic receptor agonist, or placebo for 8 weeks in double-blind trial. No overall benefit for cognitive function, but for patients on second-generation antipsychotics there was improvement in attention. Detailed analysis underway.
Shim JC, Jung DU, Jung SS, Seo YS, Cho DM, Lee JH, Lee SW, Kong BG, Kang JW, Oh MK, Kim SD, McMahon RP, Kelly DL. Adjunctive Varenicline Treatment with Antipsychotic Medications for Cognitive Impairments in People with Schizophrenia: A Randomized Double-Blind Placebo-Controlled Trial. Neuropsychopharmacology. 2012 Feb;37(3):660-8.
Department of Psychiatry
Busan Paik Hospital
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