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Awarded Trial: 07TGF-1100
Bipolar depression or major depression and amphetamine abuse/dependence
Secondary Drug Intervention
Duration of Study Period for Each Subject
YMRS, IDS-C, HVLT, Stroop, SMT, RMCPT, VAS
Sixty (60) patients with bipolar depression or major depression and amphetamine abuse were treated with citicoline up to 2000 mg/day or placebo for 12 weeks. Those on citicoline stayed in the study significantly longer and had a significant improvement in depressive symptoms. There was no difference in the two groups in amphetamine use, YMRS, or cognition.
Brown SE, Gabrielson B. A randomized, double-blind, placebo-controlled trial of citicoline for bipolar and unipolar depression and methamphetamine dependence. Journal of Affective Disorders 2012; 143:257-260.
Department of Psychiatry
UT Southwestern Medical Center
5323 Harry Hines Blvd.
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