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Awarded Trial: 07TGF-1094
Grant ID
07TGF-1094
Illness
Bipolar depression
Primary Drug/Intervention
Acetyl-L-Carnitine
Primary Dosage
1000 mg t.i.d.
Secondary Drug Intervention
Alpha-Lipoic Acid
Secondary Dosage
600 mg t.i.d.
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Brennan
Sample Size
40
Duration of Study Period for Each Subject
13 weeks
Outcome Measurements
CGI, HAM-D, YMRS, MADRS
Results
Forty (40) patients with BP depression were treated for 12 weeks with acetyl-L-carnitine and alpha-lipoic acid, thought to enhance mitochrondrial function, or placebo. There was no significant difference in depression between the two groups.
Publication
Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM. A placebo-controlled trial of acetyl-L-carnitine and รก-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol. 2013 Oct;33(5):627-35.
Link
http://www.ncbi.nlm.nih.gov/pubmed/23948785
PI Name
Brian Brennan
Degree
MD
Center
McLean Hospital
Institution
Harvard Medical School
Address
115 Mill Street
City or Town
Belmont
State or Province
MA
Zip or Postal Code
2478
Country
USA
Email Address
bbrennan@partners.org