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Awarded Trial: 06TGF-981

Grant ID

06TGF-981

Illness

Bipolar Disorder

Primary Drug/Intervention

Valacyclovir

Primary Dosage

1000 mg twice daily

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Payne

Sample Size

60

Duration of Study Period for Each Subject

16 weeks

Outcome Measurements

PANSS, CGI, YMRS, RBANS, MADRS

Results

Payne et al. randomized 60 BPI and II, average age 45, all HSV-1 positive, to valacylcovir 2 gm./d. for 16 weeks. On RBANS 10/19 (53%) on valacyclovir and 3/22 (14%) controls improved significantly on cognition but not on positive or negative symptoms. Data analysis is continuing.

Publication

Being submitted.

Link

N/A

PI Name

Jennifer Payne

Degree

MD

Center

Department of Psychiatry

Institution

The Johns Hopkins University

Address

600 N. Wolfe Street

City or Town

Baltimore

State or Province

MD

Zip or Postal Code

21287

Country

USA

Email Address

jpayne5@jhmi.edu