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Awarded Trial: 05T-670
Secondary Drug Intervention
Duration of Study Period for Each Subject
Fifty bipolar I and II patients were randomized to adjunct pramipexole 1.5 mg. or placebo to assess effect on cognition. Although it was initially hoped to use only euthymic patients, that did not prove to be feasible. 45 patients completed the study and among them the pramipexole had no significant effect on cognitive measures. However a post-hoc analysis of the 34 euthymic patients showed a significant improvement in processing speek and working memory.
Burdick KE, Braga RJ, Nnadi CU, Shaya Y, Stearns WH, Malhotra A. Placebo-Controlled Adjunctive Trial of Pramipexole in Patients with Bipolar Disorder: Targeting Cognitive Dysfunction. Journal of Clinical Psychiatry 2011.
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