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Awarded Trial: 05T-700

Grant ID

05T-700

Illness

Schizophrenia

Primary Drug/Intervention

Tropisetron

Primary Dosage

6 mg/day

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Hashimoto

Sample Size

40

Duration of Study Period for Each Subject

8 weeks

Outcome Measurements

PANSS, Rapid Visual Information Processing, Intra-Extra Dimensional Shift, WMS-R, Quality of Life Scale (QLS), and Auditory Sensory Gating P50

Results

Forty (40) patients with schizophrenia were randomized to tropisetron 10 mg/day or placebo for 8 weeks to assess possible cognitive improvement. The researchers reported significant increase in Quality of Life scores, sustained visual attention, and auditory gating P50 deficits. The statistical methods used are under discussion.

Publication

Being submitted

Link

N/A

PI Name

Kenji Hashimoto

Degree

PhD

Center

Division of Clinical Neuroscience

Institution

Chiba University Center for Forensic Mental Health

Address

1-8-1 Inohana

City or Town

Chiba

State or Province

N/A

Zip or Postal Code

260-8670

Country

Japan

Email Address

hashimoto@faculty.chiba-u.jp