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Awarded Trial: 04T-630
Secondary Drug Intervention
Duration of Study Period for Each Subject
HAM-D, YMRS, CGI, cognitive battery
This was a study of 28 patients with BP depression, randomized to memantine, max 20 mg/d for 8 wks, or placebo as an adjunct to lamotrigine. The memantine was superior to placebo in decreasing the Hamilton Depression Rating Scale (p=0.05), but the effect was maximum at 3 to 4 weeks and not sustained.
Anand A, Gunn AD, Barkay G, Karne HS, Nurnberger JI, Mathew SJ, Ghosh S. Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. Bipolar Disord. 2012 Feb;14(1):64-70.
Indiana Univeristy School of Medicine
Indiana University, Dept. of Psychiatry
550 University Blvd., UH 3114
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