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Awarded Trial: 04T-630
Grant ID
04T-630
Illness
Bipolar Depression
Primary Drug/Intervention
Memantine
Primary Dosage
10 mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Anand
Sample Size
40
Duration of Study Period for Each Subject
8 weeks
Outcome Measurements
HAM-D, YMRS, CGI, cognitive battery
Results
This was a study of 28 patients with BP depression, randomized to memantine, max 20 mg/d for 8 wks, or placebo as an adjunct to lamotrigine. The memantine was superior to placebo in decreasing the Hamilton Depression Rating Scale (p=0.05), but the effect was maximum at 3 to 4 weeks and not sustained.
Publication
Anand A, Gunn AD, Barkay G, Karne HS, Nurnberger JI, Mathew SJ, Ghosh S. Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. Bipolar Disord. 2012 Feb;14(1):64-70.
Link
http://www.ncbi.nlm.nih.gov/pubmed/22329473
PI Name
Amit Anand
Degree
MD
Center
Indiana Univeristy School of Medicine
Institution
Indiana University, Dept. of Psychiatry
Address
550 University Blvd., UH 3114
City or Town
Indianapolis
State or Province
IN
Zip or Postal Code
46202
Country
USA
Email Address
aanand@iupui.edu