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Awarded Trial: 04T-574
14 mg transdermal patch (one per week)
Secondary Drug Intervention
Duration of Study Period for Each Subject
Twenty-eight patients with schizophrenia and 32 normal controls were enrolled. Nicotine significantly improved performance on the Continuous Performance Task in both groups. Some aspects of the Continuous Performance Task improved to a greater extent in patients with schizophrenia than in controls.
Barr RS, Culhane MA, Jubelt LE, Mufti RS, Dyer MA, Weiss AP, Deckersbach T, Kelly JF, Freudenreich O, Goff DC, Evins AE. The effect of transdermal nicotine on cognition in nonsmokers with schizophrenia and nonpsychiatric controls. Neuropsychopharmacology. 2008 Feb;33(3):480-90. Epub 2007 Apr 18.
Anne Eden Evins
Harvard Medical Center
Massachusetts General Hospital
25 Staniford Street
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