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Awarded Trial: 03T-301
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, cognitive battery
Seventy patients were randomized to receive acetylsalicyclic acid or placebo given adjunctively to standard treatment. Patients randomized to acetylsalicyclic acid showed a significant benefit on the total PANSS score and the PANSS positive subscale compared to patients receiving placebo. There were no significant effects on cognitive tests. Patients who had the lowest ratio of T helper 1 to T helper 2 ratios showed the largest symptomatic improvement.
Laan W, Selten JP, Kahn RS, Huisman AM, Heijnen CJ, Grobbee DE, Burger H. Acetylsalicylic acid as an adjuvant therapy for schizophrenia. Trials. 2006 Oct 23;7:31.
Interdisciplinary Center for Psychiatric Epidemiology
University Medical Center Groningen
Hanzeplein 1 (9713 GZ), PO Box 30.001
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