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Awarded Trial: 03T-293
Grant ID
03T-293
Illness
Schizophrenia
Primary Drug/Intervention
S-Adenosyl-Methionine (SAMe)
Primary Dosage
800mg
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Strous
Sample Size
30
Duration of Study Period for Each Subject
8 weeks
Outcome Measurements
PANSS, SANS, Calgary Depression Scale, CGI, Quality of Life Scale, Overt Aggression Scale, Cognitive Battery
Results
Eighteen patients with the low-activity variant of catechol-o-methyl transferase were enrolled. There were no significant differences between drug and placebo groups on PANSS, Calgary Depression Scale or the Cognitive Battery. Patients receiving SAM-e had significant improvements on the CGI, the Quality of Life Scale and the Overt Aggression Scale.
Publication
N/A
Link
N/A
PI Name
Rael Strous
Degree
MD
Center
Beer Yaakov Mental Health Center
Institution
Sackler School of Medicine, Tel Aviv University
Address
P.O. Box 1
City or Town
Beer Yaakov
State or Province
N/A
Zip or Postal Code
70350
Country
Israel
Email Address
raels@post.tau.ac.il