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Awarded Trial: 03T-475
Grant ID
03T-475
Illness
Bipolar II depression
Primary Drug/Intervention
Lamotrigine
Primary Dosage
200 mg/day
Secondary Drug Intervention
Lithium
Secondary Dosage
at least 900mg/day
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Tamminga
Sample Size
20
Duration of Study Period for Each Subject
16 weeks
Outcome Measurements
FDG-PET
Results
This study enrolled a subgroup of 20 subjects from within a larger study comparing lithium (Li) and lamotrigine (LTG) for bipolar depression. FDG-PET data were obtained at baseline from 11 patients treated with Li and 9 patients treated with LTG. Eight normal controls were also scanned. Ten patients treated with Li were also scanned at 2 weeks, and 5 were scanned at 16 weeks. Nine patients treated with LTG were scanned at 2 weeks, and 6 were scanned at 16 weeks. Compared to normal controls, patients had lower activity in left middle frontal gyrus and left fusiform gyrus. Patients had increased activity in posterior hippocampus, medial postcentral gyrus, and cerebellum. Patients treated with Li showed an increase in activity in posterior cingulate and decreased activity in the right parietal lobe and the left precentral gyrus, compared to baseline. Patients treated with LTG showed an increase in activity in inferior temporal cortex and decreased activity in the left and right precentral gyrus, compared to baseline. Changed activity in left parahippocampal gyrus and posterior cingulate predicted response to LTG. Changed activity in left inferior parietal cortex and temporal cortex predicted a response to Li.
Publication
N/A
Link
N/A
PI Name
Carol Tamminga
Degree
MD
Center
Department of Psychiatry
Institution
UT Southwestern Medical Center
Address
5323 Harry Hines Boulevard
City or Town
Dallas
State or Province
TX
Zip or Postal Code
75390
Country
USA
Email Address
carol.tamminga@utsouthwestern.edu