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Awarded Trial: 03T-472

Grant ID

03T-472

Illness

Psychosis (first episode)

Primary Drug/Intervention

B vitamins: Folic acid and Pyridoxine and Hydroxycobalamin

Primary Dosage

5mg and 50mg and 0.4mg

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

O'Donnell

Sample Size

120

Duration of Study Period for Each Subject

3 months

Outcome Measurements

Cognitive battery, PANSS, CGI, HAM-D

Results

One hundred patients with first-episode psychosis were randomized to adjunct treatment with vitamin B6, B12, and folic acid or placebo. The treatment group improved significantly on depression symptoms and cognitive function (attention, working memory, and visual learning).

Publication

N/A

Link

N/A

PI Name

Colin O'Donnell

Degree

MB

Center

N/A

Institution

University of Melbourne

Address

35 Poplar Road, Locked Bag 10

City or Town

Parkville

State or Province

Victoria

Zip or Postal Code

3052

Country

Australia

Email Address

colin.o'donnell@mh.org.au