Back to Awarded Treatment Trials


Awarded Trial: 03T-429

Grant ID

03T-429

Illness

Bipolar Depression

Primary Drug/Intervention

Mifepristone

Primary Dosage

600 mg

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Young

Sample Size

150

Duration of Study Period for Each Subject

6 weeks

Outcome Measurements

HAM-D, YMRS, CGI

Results

60 patients with BP depression were randomized to mifepristone 600 mg/d or placebo as an adjunct for 1 week. Spatial working memory was significantly improved at 2 weeks and was sustained for 7 weeks. There was no improvement in depressive symptoms.

Publication

Watson S, Gallagher P, Porter RJ, Smith MS, Herron LJ, Bulmer S; North-East Mood Disorders Clinical Research Group, Young AH, Ferrier IN. A Randomized Trial to Examine the Effect of Mifepristone on Neuropsychological Performance and Mood in Patients with Bipolar Depression. Biol Psychiatry. 2012;72:943-949.

Link

http://www.ncbi.nlm.nih.gov/pubmed/22770649

PI Name

Allan Young

Degree

PhD

Center

University of Newcastle

Institution

University of British Columbia

Address

2255 Wesbrook Mall

City or Town

Vancouver

State or Province

British Columbia

Zip or Postal Code

V6T 2A1

Country

Canada

Email Address

alyoung@interchange.ubc.ca