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Awarded Trial: 02T-270
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, BPRS, Extrapyramidal side effects, quality of life, cognitive battery
Seventy-four patients were enrolled in the study. At three months, buspirone treatment was associated with significant improvement on the digital symbol substitution test, which measures attention and vigilance. This effect was not present at earlier time points or at 6 months. There was no significant effect on other cognitive variables or on symptom ratings.
Sumiyoshi T, Park S, Jayathilake K, Roy A, Ertugrul A, Meltzer HY. Effect of buspirone, a serotonin1A partial agonist, on cognitive function in schizophrenia: a randomized, double-blind, placebo-controlled study. Schizophr Res. 2007 Sep;95(1-3):158-68.
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