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Awarded Trial: 02T-152 & 02T-158
02T-152 & 02T-158
Secondary Drug Intervention
Duration of Study Period for Each Subject
HAM-D, Montgomery-Asperg Depression Rating Scale, MADRS, YMRS, GAF, CGI-BP
Data from 90 patients were used for the analysis. Patients receiving lithium and those receiving lamotrigine both showed a significant improvement in ratings of depression compared to baseline, but there was no significant difference between the two drugs. (Two site study for Dr. Suppes (02T-158: UTSouthwestern Medical Center) and Dr. Marangell (02T-152: Baylor College of Medicine)).
Calabrese JR, Goldberg JF, Ketter TA, Suppes T, Frye M, White R, DeVeaugh-Geiss A, Thompson TR. Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies. Biol Psychiatry. 2006 Jun 1;59(11):1061-4.
UT Southwestern Medical Center
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