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Awarded Trial: 02T-235
Grant ID
02T-235
Illness
Tardive Dyskinesia
Primary Drug/Intervention
Piracetam
Primary Dosage
2400 mg b.i.d.
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Lerner
Sample Size
40
Duration of Study Period for Each Subject
9 weeks
Outcome Measurements
Extrapyramidal symptom rating scales
Results
Thirty-one patients completed both crossover periods. Pirecetam was associated with a significant improvement in tardive parkinsonism (44%), and tardive dyskinesia (40%).
Publication
Libov I, Miodownik C, Bersudsky Y, Dwolatzky T, Lerner V. Efficacy of piracetam in the treatment of tardive dyskinesia in schizophrenic patients: a randomized, double-blind, placebo-controlled crossover study. J Clin Psychiatry. 2007 Jul;68(7):1031-7.
Link
http://www.ncbi.nlm.nih.gov/pubmed/17685739
PI Name
Vladimir Lerner
Degree
MD
Center
Be'er Sheva Mental Health Center
Institution
Ben Gurion University of the Negev
Address
P.O. Box 4600
City or Town
Be'er Sheva
State or Province
N/A
Zip or Postal Code
84170
Country
Israel
Email Address
lernervld@yahoo.com