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Awarded Trial: 02T-181

Grant ID

02T-181

Illness

Bipolar Disorder

Primary Drug/Intervention

Celecoxib

Primary Dosage

200mg b.i.d.

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Soares

Sample Size

28

Duration of Study Period for Each Subject

6 weeks

Outcome Measurements

HAM-D, YMRS, CGI-BP, UKU side-effects scale

Results

Twenty eight patients completed the trial. Patients receiving celecoxib had a significant improvement on depression ratings at week 1, which did not persist in the subsequent weeks of the trial.

Publication

Nery FG, Monkul ES, Hatch JP, Fonseca M, Zunta-Soares GB, Frey BN, Bowden CL, Soares JC. Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study. Hum Psychopharmacol. 2008 Mar;23(2):87-94.

Link

http://www.ncbi.nlm.nih.gov/pubmed/18172906

PI Name

Jair Soares

Degree

MD

Center

Health Science Center at San Antonio

Institution

The University of Texas

Address

7703 Floyd Curl Drive

City or Town

San Antonio

State or Province

TX

Zip or Postal Code

78229

Country

USA

Email Address

soares@uthscsa.edu