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Awarded Trial: 01T-436
Secondary Drug Intervention
Duration of Study Period for Each Subject
Forty two schizophrenic patients with plasma homocysteine above 15 micromoles per liter were treated with folic acid + B12 + pyridoxine for three months and with placebo for three months in a randomized, blinded, crossover design. Homocysteine levels declined on vitamin therapy compared to placebo. There was a signifcant reduction in total PANSS score and an improvement on the Wisonsin Card Sort test during the vitamin treatment.
Levine J, Stahl Z, Sela BA, Ruderman V, Shumaico O, Babushkin I, Osher Y, Bersudsky Y, Belmaker RH. Homocysteine-Reducing Strategies Improve Symptoms in Chronic Schizophrenic Patients with Hyperhomocysteinemia. Biological Psychiatry 2006 Aug 1;60(3):265-9.
Beersheva Mental Health Center
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