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Awarded Trial: 01T-101
300 mg b.i.d.
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, extrapyramidal symptoms rating scale, electrophysiological recordings, MANOVA
A double blind, randomized, placebo-controlled crossover study of adjunctive allopurinol in 35 patients with poorly responsive schizophrenia was conducted. Allopurinol was well tolerated and produced significant treatment effects on the PANSS total score as well as the positive, negative, and general subscales.
Brunstein MG, Ghisolfi ES, Ramos FL, Lara DR. A clinical trial of adjuvant allopurinol therapy in moderately refractory schizophrenia. J Clin Psychiatry. 2005 Feb;66(2):213-9.
Faculdade de Biociencias
Pontificia Universidade Catolica PUCRS
Av. Ipiranga, 6681, Pd 12 A
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