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Awarded Trial: 01T-407

Grant ID

01T-407

Illness

Schizophrenia

Primary Drug/Intervention

Modafinil

Primary Dosage

200 mg

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Pierre

Sample Size

20

Duration of Study Period for Each Subject

8 weeks

Outcome Measurements

SANS, BPRS, CGI, QOL, CVLT, DS-CPT, Trails B, Somatic Measurements (Sleep, Weight, Glucose, Lipids)

Results

Twenty patients with schizophrenia were randomized to receive modafanil 200 mg given adjunctively to antipsychotics or placebo for 8 weeks. Modafinil treatment had no effect on SANS, BPRS, quality of life or cognitive scales.

Publication

Pierre JM, Peloian JH, Wirshing DA, Wirshing WC, Marder SR. A Randomized, Double-Blind, Placebo-Controlled Trial of Modafinil for Negative Symptoms in Schizophrenia. J Clin Psychiatry. 2007 May;68(5):705-10.

Link

http://www.ncbi.nlm.nih.gov/pubmed/17503979

PI Name

Joseph Pierre

Degree

MD

Center

N/A

Institution

VA Greater Los Angeles Health Care System

Address

11301 Wilshire Blvd, Bldg. 210 A, B-151H

City or Town

Los Angeles

State or Province

CA

Zip or Postal Code

90073

Country

USA

Email Address

drjoe@ucla.edu