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Awarded Trial: 01-122
Secondary Drug Intervention
Duration of Study Period for Each Subject
Ten patients with bipolar disorder received mexiletine or placebo adjunctively to other psychotropic medications for three weeks. Although the small sample size precluded accurate statistical comparisons, mexiletine treated patients appeared to have improved scores on the Young Mania Rating Scale (YMRS). There also appeared to be a greater number of "responders" (reduction of YMRS score by 50%) in the mexiletine group at week 1 and week 2.
Schaffer A, Levitt AJ. Double-blind, placebo-controlled pilot study of mexiletin for acute mania or hypomania (letter). J Clin Psychopharmacol 2005;25:507-508.
University of Toronto, Department of Psychiatry
Sunnybrook & Women's College Health Sciences Centre
2075 Bayview Ave, Room FG 29
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