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Awarded Trial: 01-074
Risperidone Added to Clozapine
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, CGI-S, CDS, GAF, QLS
30 patients with schizophrenia who had partial response to clozapine received either placebo or risperidone augmentation in a six week double-blind, randomized, design. Both groups improved on a variety of measures of psychopathology but there was significantly greater improvement in placebo treated patients on the PANSS positive subscale. In evaluating the results it may be noteworthy that duration of illness, clozapine dose and number of previous hospitaizations were higher in the group that received risperidone.
Anil Yagcioglu AE, Kivircik Akdede BB, Turgut TI et al. A double-blind controlled study of adjunctive treatment with risperidone in schizophrenic patients partially responsive to clozapine: efficacy and safety. J Clin Psychiatry. 2005 Jan;66(1):63-72. Kivircik Akdede BB, Anil Yagcioglu AE, Alptekin K et al. A double-blind study of combination of clozapine with risperidone in patients with schizophrenia: effects on cognition. J Clin Psychiatry. 2006 Dec;67(12):1912-9.
Department of Psychiatry
Hacettepe University, Faculty of Medicine
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