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Awarded Trial: 01-025

Grant ID

01-025

Illness

Schizophrenia

Primary Drug/Intervention

Repeated Transcranial Magnetic Stimulation (rTMS)

Primary Dosage

1 Hz

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Fitzgerald

Sample Size

33

Duration of Study Period for Each Subject

2 weeks

Outcome Measurements

Hullucination Change Scale, PSYRATS, PANSS, Hopkins Verbal Learning Test, Verbal Fluency, Digit Span, Brief Visuospatial Memory Test-Revised, Visuospatial Digit Span

Results

Thirty three patients with treatment resistant auditory hallucinations were randomized to receive rTMS or sham for 10 consecutive days over the temporoparietal cortex. The treatment was for 15 minutes at 1 Hz and 90% of resting motor threshold. There was no clinically significant difference between active and sham treatment, but a modest reduction in the loudness of hallucinations was observed.

Publication

Fitzgerald PB, Brown TL, Marston NA, Daskalakis ZJ, De Castella A, Kulkarni J. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2003 Oct;60(10):1002-8.

Link

http://www.ncbi.nlm.nih.gov/pubmed/14557145

PI Name

Paul Fitzgerald

Degree

MBBS

Center

Alfred Psychiatry Research Centre

Institution

The Alfred Hospital

Address

Commercial Road

City or Town

Prahran

State or Province

Victoria

Zip or Postal Code

3181

Country

Australia

Email Address

p.fitzgerald@alfred.org.au