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Awarded Trial: BPN-2
Ethyl Eicosapentanoic Acid
Secondary Drug Intervention
Duration of Study Period for Each Subject
Inventory of Depressive Symptoms, CGI-BP
Fifty nine subjects with bipolar depression and 62 subjects with rapid cycling bipolar disorder were randomized to receive 6 grams per day of ethyl-eicosapentanoic acid (EPA) or placebo adjunctive to mood stabilizers for 4 months. There was no significant difference betwen EPA or placebo for rating of depression (Inventory of Depressive Symptoms) or rapid cycling (CGI-BP).
Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RM. Double-Blind, Randomized, Placebo-Controlled Trials of Ethyl-Eicosapentanoate in the Treatment of Bipolar Depression and Rapid Cycling Bipolar Disorder. Biol Psychiatry. 2006 Nov 1;60(9):1020-2.
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