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Awarded Trial: 97-RC-301-2
Secondary Drug Intervention
Duration of Study Period for Each Subject
up to 5 months
YMRS, CDRS-R, CGAS
Fifty-three offspring of a parent with bipolar disorder (aged 5-17) and meeting diagnostic criteria for cyclothymia or bipolar disorder not otherwise specified were randomized to receive divalproex or placebo for up to 5 years. There was no significant difference between the two groups for time to relapse. In a post-hoc analysis, patients with the greatest degree of genetic risk tended to respond better to divalproex than to placebo.
Findling RL, Frazier TW, Youngstrom EA, McNamara NK, Stansbrey RJ, Gracious BL, Reed MD, Demeter CA, Calabrese JR. Double-Blind, Placebo-Controlled Trial of Divalproex Monotherapy in the Treatment of Symptomatic Youth at High Rish for Developing Bipolar Disorder. Journal of Clinical Psychiatry 68:5, 781-788, 2007.
Case Western Reserve University, Child and Adolescent Psychiatry
University Hospitals of Cleveland
11100 Euclid Avenue
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