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Awarded Trial: 07TGS-1029
Bipolar Disorder and Schizoaffective Disorder
50 mg, then 100 mg
Secondary Drug Intervention
.25 mg, then .05 mg
Duration of Study Period for Each Subject
YMRS, MACS Rating Scale
This study compared pentazocine, an opiate, to lorazepam in patients with mania (bipolar or schizoaffective). Twenty patients were assigned to 100 mg pentazocine for 1 day or 0.5 mg of lorazepam for 1 day, then crossed over to the other drug on day 2. They were rated on the MACS (manic acute change scale) and YMRS. No difference was found in ratings between the two drugs.
Cohen BM, Murphy B. The effects of pentazocine, a kappa agonist, in patients with mania. Int J Neuropsychopharmacol. 2008 Mar;11(2):243-7.
Frazier Research Institute
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