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Awarded Trial: 05T-742
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, BPRS, MINI, MADRS, ASC
180 women between ages of 18-45 with schizophrenia or schizoaffective disorder on antipsychotic medication were randomized to receive either transdermal estradiol 200 mcg, transdermal estradiol 100mcg, or a placebo patch. Both estradiol groups showed improvement in symptoms, as measured by decreases in PANSS positive, general, and total scores compared to the placebo group. A greater effect was observed in the higher dose of estradiol.
Kulkarni J, Gavrilidis E, Wang W, Worsley R, Fitzgerald PB, Gurvich C, Van Rheenen T, Berk M, Burger H. Estradiol for treatment-resistant schizophrenia: a large-scale randomize-controlled trial in women of child-bearing age. Mol Psychiatry. 2015 Jun;20(6):695-702.
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