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Awarded Trial: 05T-704
Secondary Drug Intervention
Duration of Study Period for Each Subject
Cocaine Craving Questionnaire , Hamilton Rating Scale, Quick Inventory of Depressive Symptomatology-SR, Young Mania Rating Scale, Barratt Impulsiveness Scale, Rey Auditory Verbal Learning Test, STROOP color-word task, Addiction Severity Index, PRD-III
One hundred twenty (120) patients with bipolar disorder and cocaine dependence randomized to lamotrigine up to 400 mg/day or placebo control for 10 weeks. Data were available for 112 individuals. Lamotrigine was associated with a nonsignificant decrease in cocaine use in the first 2 weeks, but the effect appeared to wear off, and there was no difference at week 10. The lamotrigine also had no significant effect on symptoms or cognition.
Brown ES, Sunderajan P, Hu LT, Sowell SM, Carmody TJ. A Randomized, Double-Blind, Placebo-Controlled, Trial of Lamotrigine Therapy in Bipolar Disorder, Depressed or Mixed Phase and Cocaine Dependence. Neuropsychopharmacology 2012; 37:2347-2354.
E. Sherwood Brown
Southwestern Medical Center at Dallas
University of Texas
5323 Harry Hines Boulevard
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