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Awarded Trial: 03T-439
Bipolar Disorder and Cocaine Abuse/Dependence
up to 2000mg
Secondary Drug Intervention
Duration of Study Period for Each Subject
HRSD, IDS-SR, YMRS, cognitive battery
Forty-four patients with mania or hypomania and cocaine dependence were enrolled. The citicoline group demonstrated a statistically significant effect on auditory verbal learning. There were no significant effects on mood ratings. Patients who received placebo had 6.41 times higher odds of testing positive for cocaine compared to the citicoline group. Citicoline is an over-the-counter supplement with effects on membrane phospholipids and cerebral metabolism.
Brown ES, Gorman AR, Hynan LS. A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence. J Clin Psychopharmacol. 2007 Oct;27(5):498-502.
E. Sherwood Brown
Southwestern Medical Center at Dallas
University of Texas
5323 Harry Hines Boulevard
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