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Awarded Trial: 02-STN-005
1 gram twice daily
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, RBANS, WRAT III, MCAS
Valcyvlovir 1 gram twice daily was administered to 65 outpatients with schizophrenia for 16 weeks in an open-label, adjunctive trial. In patients that were seropositive for cytomegalovirus (N=21), but not other herpesviruses, there was a significant improvement in the sum of PANSS positvie and negative symptom scores (Effect size =0.85).
Dickerson FB, Boronow JJ, Stallings CR, Origoni AE, Yolken RH. Reduction of symptoms by valcyclovir in cytomegalovirus-seropositive individuals with schizophrenia. Am J Psychiatry. 2003 Dec;160(12):2234-6.
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