The following information on selected repurposed drugs was published in Clinical Schizophrenia and Related Psychoses in January 2012 by Drs. E. Fuller Torrey and John M. Davis. The drugs listed are those for which treatment trials have been supported by SMRI. This database will be updated as new information on these drugs becomes available.

The 9 drugs discussed include the following:

-Aspirin: No update available

-Celecoxib:

1) Although not performed on patients with schizophrenia or bipolar disorder, a study by Dr. Sayyah from the Univeristy of Jundishapur in Iran reported that celecoxib, given together with fluoxetine, improved symptoms in patients with obsessive-compulsive disorder.

 http://www.ncbi.nlm.nih.gov/pubmed?term=Sayyah celecoxib

-Estrogen/Raloxifene: No update available

-Folate: No update available

-Minocycline: No update available

-Mirtazapine: No update available

-Omega-3 Fatty Acids (fish oil): No update available

-Pramipexole:

1) A paper by Dr. Burdick from the Mt. Sinai School reported that overall, Pramipexole did not improve cognition in patients with bipolar disorder. However, the effect of the drug on cognition was influenced by the presence or absence of mood symptoms, and additional analyses focusing on those patients who were neither depressed nor manic showed that they did experience some improvement in their cognitive abilities.

http://www.ncbi.nlm.nih.gov/pubmed/22152405 

-Pregnenolone: No update available