In recent years, SMRI has provided funds to the for-profit, corporate biotechnology sector to develop promising compounds for the treatment of schizophrenia and bipolar disorder. As of May 2008, SMRI had existing collaborations with the following companies:

Company

Indication

Project

Status

Acadia Pharmaceuticals
San Diego, CA

Schizophrenia

ACP-104 (des-methylclozapine)

Phase II

Argolyn Biosciences
North Charleston, SC

Schizophrenia

ABS-201, a neurotensin analogue

Preclinical Development

Avera Pharmaceuticals
San Diego, CA

Schizophrenia

AV965, a serotonin 5-HT1A partial agonist

Phase I

Biovalve Technologies
Westborough, MA

Schizophrenia

BT-100, a dopamine D1 receptor agonist

Phase II

Houston Pharma
Bellaire, TX

Schizophrenia

Idazoxan, an α2 antagonist

Phase II

Marinus Pharmaceuticals
New Haven, CT

Bipolar Disorder and
Schizophrenia

Chelerythrine, an inhibitor of protein kinase C

Preclinical Development

Memory Pharmaceuticals
Montvale, NJ

Cognitive Deficits in Schizophrenia

MEM 3454, a nicotinic α7 agonist

Phase II

Omeros
Seattle, WA

Psychosis

Phosphodiesterase 10 inhibitor

Preclinical Development

Repligen
Waltham, MA

Bipolar Depression

Uridine

Phase II

At this time, available SMRI funds are fully committed and new proposals are not being accepted.