In recent years, SMRI has provided funds to the for-profit, corporate biotechnology sector to develop promising compounds for the treatment of schizophrenia and bipolar disorder. As of May 2008, SMRI had existing collaborations with the following companies:
|
Company |
Indication |
Project |
Status |
|
Acadia Pharmaceuticals San Diego, CA |
Schizophrenia |
ACP-104 (des-methylclozapine) |
Phase II |
|
Argolyn Biosciences North Charleston, SC |
Schizophrenia |
ABS-201, a neurotensin analogue |
Preclinical Development |
|
Avera Pharmaceuticals San Diego, CA |
Schizophrenia |
AV965, a serotonin 5-HT1A partial agonist |
Phase I |
|
Biovalve Technologies Westborough, MA |
Schizophrenia |
BT-100, a dopamine D1 receptor agonist |
Phase II
|
Houston Pharma Bellaire, TX |
Schizophrenia
|
Idazoxan, an α2 antagonist
|
Phase II
|
|
Marinus Pharmaceuticals New Haven, CT |
Bipolar Disorder and Schizophrenia |
Chelerythrine, an inhibitor of protein kinase C |
Preclinical Development |
|
Memory Pharmaceuticals Montvale, NJ |
Cognitive Deficits in Schizophrenia |
MEM 3454, a nicotinic α7 agonist |
Phase II |
|
Omeros Seattle, WA |
Psychosis |
Phosphodiesterase 10 inhibitor |
Preclinical Development |
|
Repligen Waltham, MA |
Bipolar Depression |
Uridine |
Phase II |
At this time, available SMRI funds are fully committed and new proposals are not being accepted.