Stanley Brain Research Laboratory and Brain Collection

The Stanley Brain Research Laboratory, part of The Stanley Medical Research Institute, is located in Gaithersburg, Maryland. It is directed by Drs. Maree J. Webster and E. Fuller Torrey.  The Stanley Brain Collection is a widely used resource for researchers trying to find the causes of, and better treatments for, schizophrenia and bipolar disorder (manic-depressive illness).  Currently two cohorts are available for study; the Neuropathology Consortium consisting of 60 cases (15 each schizophrenia, bipolar disorder, depression, and controls) and the Array Collection consisting of 105 cases (35 each schizophrenia, bipolar disorder and controls).

• An Introduction to the Stanley Brain Collection

• An Article Describing the Stanley Brain Collection

• Neuropathology Consortium

• Publications and Papers Submitted or in Press

• Integrative Database includes 1749 neuropthological markers measured in 12 different brain regions in the Consortium Collection combined with microarray data and statistical tools. A Repository of raw data is also included. Kim & Webster, Neuropsychopharmacology 2009, 1-10

• Array Collection

• Publications and Papers Submitted or in Press

• Access SMRI’s Brain Databases
  

  • Microarray Data from multiple brain areas from both the Consortium Collection and Array Collection. A thorough collection of gene expression summaries are provided, inclusive of patient demographics, disease subclasses, regulated biological pathways, and functional classifications. Raw data is also available to download. Higgs et al., BMC genomics 2006,7:70

• A Public Statement about the Stanley Brain Collection
  

In addition to overseeing the brain collection, the laboratory conducts research on the neuropathology of schizophrenia and bipolar disorder and on brain development. Many studies carried out at the Stanley Brain Research Laboratory are done in cooperation with studies at the Stanley Laboratory of Developmental Neurovirology.