Neuropathology Consortium

The Neuropathology Consortium is a collection of 60 brains, consisting of 15 each diagnosed with schizophrenia, bipolar disorder, or major depression, and unaffected controls. The four groups are matched by age, sex, race, postmortem interval, pH, side of brain, and mRNA quality.

Demographic Table

 SchizophreniaBipolar DisorderMajor DepressionNormal Control Subjects
Age (y)44.2 (25-62)42.3 (25-61)46.5 (30-65)48.1 (29-68)
Gender9 M, 6 F9 M, 6 F9 M, 6 F9 M, 6 F
Race12 C, 3 A14 C, 1 AA15 C14 C, 1 AA
PMI (hrs)33.7 (12-61)32.5 (13-62)27.5 (7-47)23.7 (8-42)
pH6.1 (5.8-6.6)6.2 (5.8-6.5)6.2 (5.6-6.5)6.3 (5.8-6.6)
hemisphere6 R, 9 L8 R, 7 L6 R, 9 L7 R, 8 L

Sample Availability

M, male; F, female; C, Caucasian; AA, African American; Asian; L, left; R, right.

AreaSampleAmountConcentration
Caudal CingulateRNA5 ug500 ng/ul
Caudal Cingulateprotein20 ug1 ug/ul
ParietalRNA2 ug500 ng/ul
Parietalprotein20 ug1 ug/ul
Premotor cx (BA6)RNA2 ug500 ng/ul
Premotor cx (BA6)protein20 ug1 ug/ul
Occipital cortexRNA2 ug500 ng/ul
Occipital cortexDNA2 ug10 ng/ul
Orbital frontalprotein20 ug2 ug/ul
Cerebellumprotein20 ug1 ug/ul
CerebellumRNA2 ug500 ng/ul
CerebellumDNA2 ug10 ng/ul
SpleenDNA2 ug10 ng/ul
LiverDNA2 ug10 ng/ul

SECTIONS

Fresh frozen, 14um thick sections, mounted on glass slides 1.5” x 3.0” are available from the following areas:

Orbital frontal cortexAmygdala
Superior temporal cortexThalamus
Anterior cingulate cortexUpper midbrain
Occipital cortexUpper pons
Nucleus accumbensCerebellum
Caudate nucleusAnterior hippocampus (8 cases depleted)
Anterior Commissure  (caudate/putamen)

Fixed paraffin, 10um thick sections are available from the following areas:

Orbital frontal cortexNucleus accumbens
Superior temporal cortexAnterior hippocampus
Anterior cingulate cortexMid hippocampus
Occipital cortexAmygdala
Striatum

BLOCKS

Frozen ~300mg blocks are available from the following areas:

Premotor cortex (BA6)Cerebellum
Motor cortex (BA4)Liver
Parietal cortex (BA7)Spleen
Visual association cortex (BA19)

Fixed blocks are available from the following areas:

Premotor cortex (BA6)Parietal cortex (BA7)
Motor cortex (BA4)Visual association cortex (BA19)
Caudal Cingulate cortex (BA23 & 31)

Request Samples

Neuropathology Consortium Studies Publications

Stanley maintains a list of publications based on research arising from SMRI Neuropathology Consortium studies.

See Publications