Array Collection Publications

Publications Arising from Array Collection Studies


  1. Abdolmaleky HM, Yaqubi S, Papageorgis P, Lambert AW, Ozturk S, Sivaraman V, Thiagalingam S. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res 2011;129(2-3):183-190.
  2. Akula N, Barb J, Jiang X, Wendland JF, Choi KH, Sen SK, Hou L, Chen DTW, Laje G, Johnson K, Lipska BK, Kleinman JE, Corrada-Bravo H, Detera-Wadleigh S, Munson PJ, McMahon FJ. RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms, and GTPase binding in bipolar disorder. Mol Psychiatry 2014;19(11):1179-1185.
  3. Akula N, Wendland JR, Choi KH, McMahon FJ. An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder. Neuropsychopharmacology 2016; 41: 886-895.
  4. Amano K, Yamada K, Iwayama Y, Detera-Wadleigh SD, Hattori E, Toyota T, Tokunaga K, Yoshikawa T, Yamakawa K. Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder. Psychiatr Genet 2008;18(1):1-10.
  5. Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N. Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. Am J Med Genet Part B 200;150B:967-976.
  6. Atz ME, Rollins B, Vawter MP. NCAM1 association study of bipolar disorder and schizophrenia: polymoprphisms and alternatively spliced isoforms lead to similarities and differences. Psychiatr Genet 2007;17(2):55-67.
  7. Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ. Dysregulation of miR-34a Links Neuronal Development to Genetic Risk Factors for Bipolar Disorder. Mol Psychiatry 2015;20(5):573-584.
  8. Bavamian S, Mellios N, Lalonde J, et al. Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder. Mol Psychiatry 2015; 20: 573-584.
  9. Beasley CL, Honer WG, Ramos-Miguel A, Vila-Rodriguez F, Barr AM. Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression. Schizophr Res 2017;
  10. Behan AT, Byrne C, Dunn MJ, Cagney G, Cotter DR. Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression. Mol Psychiatry 2009;14(6):601-613.
  11. Bergon A, Belzeaux R, Comte M, et al. CXCR1 is dysregulated in blood and brain from schizophrenia patients. Schizophr Res 2015;168(1-2):434-43.
  12. Bertolino A, Fazio L, Caforio G, Blasi G, Rampino A, Romano R, Di Giorgio A, Taurisano P, Papp A, Pinsonneault J, Wang D, Nardini M, Popolizio T, Sadee W. Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia. Brain 2009;132(Pt 2):417-425.
  13. Brüne M, Schöbel A, Karau R, Benali A, Faustmann PM, Juckel G, Petrasch-Parwez E. Von Economo neuron density in the anterior cingulate cortex is reduced in early onset schizophrenia. Acta Neuropathol 2010;119(6):771-778.
  14. Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T, Iwamoto K. Increased L1 retrotransposition in the neuronal genome in schizophrenia. Neuron 2014;81(2):306-313.
  15. Burnet PWJ, Eastwood SL, Bristow GC, Godlewska BR, Sikka P, Walker M, Harrison PJ. D-amino acid oxidase activity and expression are increased in schizophrenia. Mol Psychiatry 2008;13(7):658-660.
  16. Catts VS, Weickert CS. Gene expression analysis implicates a death receptor pathway in schizophrenia pathology. PLoS One 2012;7(4):e35511.
  17. Chan MK, Tsang TM, Harris LW, Guest PC, Holmes E, Bahn S. Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients. Mol Psychiatry 2011;16(12):1189-1202.
  18. Chen C, Cheng L, Grennan K, Pibiri F, Zhang C, Badner JA; Members of the Bipolar Disorder Genome Study (BiGS) Consortium, Gershon ES, Liu C. Two gene co-expression modules differentiate psychotics and controls. Mol Psychiatry 2013;18(12):1308-1314.
  19. Chen Q, Che R, Wang X, O’Neill FA, Walsh D, Tang W, Shi Y, He L, Kendler KS, Chen X. Association and expression study of synapsin III and schizophrenia. Neurosci Lett 2009;465(3):248-251.
  20. Chen Q, Wang X, O’Neill FA, Walsh D, Kendler KS, Chen X. Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia? Schizophr Res 2008;106:200-207.
  21. Chen X, Wang X, Chen Q, Williamson V, van den Oord E, Maher BS, O’Neill FA, Walsh D, Kendler KS. MEGF10 association with schizophrenia. Biol Psychiatry 2008;63(5):441-448.
  22. Choi K, Le T, Xing G, Johnson LR, Ursano RJ. Analysis of kinase gene expression in the frontal cortex of suicide victims: implications of fear and stress. Front Behav Neurosci 2011;5:1-9.
  23. Choi KH, Higgs BW, Wendland JR, Song J, McMahon FJ, Webster MJ. Gene expression and genetic variation data implicate PCLO in bipolar disorder. Biol Psychiatry 2011;89(4):353-359.
  24. Cox DA, Gottschalk MG, Wesseling H, Ernst A, Cooper JD, Bahn S. Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology. Schizophr Res 2016; 177: 98-107.
  25. Darby MM, Yolken RH, Sabunciyan S. Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders.Transl Psychiatry. 2016 Sep 13;6(9):e890. doi: 10.1038/tp.2016.173
  26. De Baumont A, Maschietto M, Lima L, Carraro DM, Olivieri EH, Fiorini A, Barreta LA, Palha JA, Belmonte-de-Abreu P, Moreira Filho CAM, Brentani H. Innate immune response is differentially dysregulated between bipolar disease and schizophrenia. Schizophr Res 2015;161(2-3):215-221.
  27. De Luca V, Hlousek D, Likhodi O, Van Tol HH, Kennedy JL, Wong AH. The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses. Genes Brain Behav 2006;5(1):107-110.
  28. De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH. Gene expression of tryptophan hydroxylase 2 in post-mortem brain of suicide subjects. Int J Neuropsychopharmacol 2006;9(1):21-25.
  29. De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH. Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia. Acta Psychiatr Scand 2006;114(3):211-215.
  30. De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia.
    Psychopharmacology (Berl). 2005;183(3):378-382.
  31. Diem O, Schäffner M, Seifarth W, Leib-Mösch C. Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells. PLoS One 2012;7(1):e30054.
  32. Dracheva S, Chin B, Haroutunian V. Altered serotonin 2C receptor RNA splicing in suicide: association with editing. NeuroReport 2008;19(3):379-382.
  33. Dracheva S, Patel N, Woo DA, Marcus SM, Siever LJ, Haroutunian V. Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. Mol Psychiatry 2007;13(11):1001-1010.
  34. Eastwood SL, Harrison PJ. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. Neuropsychopharmacology 2008;33(4):933-945.
  35. Eastwood SL, Harrison PJ. Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder. Biol Psychiatry 2010;67(11):1010-1016.
  36. Elashoff M, Higgs BW, Yolken RH, Knable MB, Weis S, Webster MJ, Barci BM, Torrey EF. Meta-analysis of 12 genomic studies in bipolar disorder. J Mol Neurosci 2007;31(3):221-244.
  37. Ellis SE, Panitch R, West AB, Arking DE. Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. Transl Psychiatry. 2016  24;6:e817. doi: 10.1038/tp.2016.87
  38. English JA, Dicker P, Föking M, Dunn MJ, Cotter DR. 2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease. Proteomics 2009;9(12):3368-3382.
  39. Ernst C, Nagy C, Sangyheon K, Yang JP, Deng X, Hellstrom IC, Choi KH, Gershenfeld H, Meaney MJ, Turecki G. Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry 2011;70(4):312-319.
  40. Etain B, Dumaine A, Mathieu F, Chevalier F, Henry C, Kahn J-P, Deshommes J, Bellivier F, Leboyer M, Jamain S. A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain. Mol Psychiatry 2010;15(7):748-755.
  41. Feldcamp LA, Souza RP, Romano-Silva M, Kennedy JL, Wong AH. Reduced prefrontal cortex DARPP-32 mRNA in completed suicide victims with schizophrenia. Schizophr Res 2008;103(1-3):192-200.
  42. Fellerhoff B, Wank R. Increased prevalence of Chlamydophila DNA in post-mortem brain frontal cortex from patients with schizophrenia. Schizophr Res 2011;129(2-3):191-195.
  43. Föcking M, Dicker P, English JA, Schubert KO, Dunn MJ, Cotter DR. Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3. Arch Gen Psychiatry 2011;68(5):477-488.
  44. Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cagney G, Cotter DR. Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia. Mol Psychiatry 2015;20(4):424-32.
  45. Föcking M, Dicker P, Lopez LM, Hryniewiecka M, Wynne K, English JA, Cagney G, Cotter DR. Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder. Transl Psychiatry. 2016 Nov; 6(11): e959
  46. Frank O, Giehl M, Zheng C, Hehlmann R, Leib-Mösch C, Seifarth W. Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorders. J Virol 2005;79(17):10890-10901.
  47. Fuke S, Kametani M, Kato T. Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia. Neurosci Lett 2008 439(2):173-177.
  48. Fung SJ, Fillman SG, Webster MJ, Weickert CS. Schizophrenia and bipolar disorder show both common and distinct changes in cortical interneuron markers. Schizophr Res 2014;155(1-3):26-30.
  49. Gabriele JP, Pontoriero GF, Thomas N, Ferro MA, Mahadevan G, Maccrimmon DJ, Pristupa ZB, Mishra RK. Antipsychotic drug use is correlated with CRP40/mortalin mRNA expression in the dorsolateral prefrontal cortex of human postmortem brain specimens. Schizophr Res 2010;119(1-3):228-231.
  50. Gamazon ER, Badner JA, Cheng L, Zhang C, Zhang D, Cox NJ, Gershon ES, Kelsoe JR, Greenwood TA, Nievergelt CM, Chen C, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI, Edenberg HJ, Foroud T, Koller DL, Scheftner WA, Coryell W, Rice J, Lawson WB, Nwulia EA, Hipolito M, Byerley W, McMahon FJ, Schulze TG, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Liu C. Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry 2013;18(3):340-346.
  51. Gershon ES, Grennan K, Busnello J, Badner JA, Ovsiew F, Memon S, Alliey-Rodriguez N, Cooper J, Romanos B, Liu C. A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain. Molecular Psychiatry2014;19: 890–894; doi:10.1038/mp.2013.107
  52. Gigante AD, Andreazza AC, Lafer B, Yatham LN, Beasley CL, Young LT. Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia. Neurosci Lett. 2011;505(1):47-51.
  53. Guella I, Sequeira A, Rollins B, Morgan L, Torri F, van Erp TG, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Bunney WE, Potkin SG, Macciardi F, Vawter MP. Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex. J Psychiatr Res 2013;47(9):1251-1221.
  54. Guintivano J, Brown T, Newcomer A, Jones M, Cox O, Maher BS, Eaton WW, Payne JL, Wilcox HC, Kaminsky ZA. Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. Am J Psychiatry 2014;171(12):1287-1296.
  55. Hamazaki K, Choi KH, Kim HY. Phospholipid profile in the postmortem hippocampus of patients with schizophrenia and bipolar disorder: no changes in docosahexaenoic acid species. Psychiatr Res 2010;44(11):688-693.
  56. Harris LW, Pietsch S, Cheng TM, Schwarz E, Guest PC, Bahn S. Comparison of peripheral and central schizophrenia biomarker profiles. PLoS One 2012;7(10):e46368.
  57. Harris LW, Wayland M, Lan M, Ryan M, Giger T, Lockstone H, Wuethrich I, Mimmack M, Wang L, Kotter M, Craddock R, Bahn S. The cerebral microvasculature in schizophrenia: a laser capture microdissection study. PLoS One 2008;3(12):e3964.
  58. Harrison PJ, Laatikainen LM, Tunbridge EM, Eastwood SL. Human brain weight is correlated with expression of the ‘housekeeping genes’ beta-2-microglobulin (beta-2M) and TATA-binding protein (TBP). Neuropathol Appl Neurobiol 2010;36(6):498-504.
  59. Hercher C, Chopra V, Beasley CL. Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder. J Psychiatry Neurosci 2014;39(6):376-385.
  60. Hess JL1 Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M; , Tsuang MT, Glatt SJ. Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia.
    Schizophr Res. 2016 Oct;176(2-3):114-124. doi: 10.1016/j.schres.2016.07.006.
  61. Higgs BW, Elashoff M, Richman S, Barci B. An online database for brain disease research. BMC Genomics 2006;7:70.
  62. Hobbs JA. Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex. J Neurovirol 2006;12(3):190-199.
  63. Ide M, Muratake T, Yamada K, Iwayama-Shigeno Y, Iwamoto K, Takao H, Toyota T, Kaneko N, Minabe Y, Nakamura K, Kato T, Mori N, Asada T, Someya T, Yoshikawa T. Genetic and expression analyses of FZD3 in schizophrenia. Biol Psychiatry 2004;56(6):462-465.
  64. Iwamoto K, Bundo M, Kato T. Altered expression of mitochrondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 2005;14(2):241-253.
  65. Iwamoto K, Bundo M, Yamada K, Takao H, Iwayama-Shigeno Y, Yoshikawa T, Kato T. DNA methylation status of SOX10 correlates with its downregulation and oligodentrocyte dysfunction in schizophrenia. J Neurosci 2005;25(22):5376-5381.
  66. Iwamoto K, Ueda J, Bundo M, Nakano Y, Kato T. Effect of a functional single nucleotide polymorphism in the 2’,3’-cyclic nucleotide 3’-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia. Psychiatry Clin Neurosci. 2008;62(1):103-108.
  67. Jackson KJ, Fanous AH, Chen J, Kendler KS, Chen X. Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder. Psychiatr Genet 2013;23(1):20-28.
  68. Kakiuchi C, Ishiwata M, Kametani M, Nelson C, Iwamoto K, Kato T. Quantitative analysis of mitochrondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia. Int J Neuropsychopharmacol 2005;8(4):515-522.
  69. Kaminsky Z, Jones I, Verma R, Saleh L, Trivedi H, Guintivano J, Akman R, Zandi P, Lee RS, Potash JB. DNA methylation and expression of KCNQ3 in bipolar disorder. Bipolar Disord 2015;17(2):150-159.
  70. Kaminsky Z, Tochigi M, Jia P, Pal M, Mill J, Kwan A, Ioshikhes I, Vincent JB, Kennedy JK, Strauss J, Pai S, Wang SC, Petronis A. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Mol Psychiatry 2012;17(7):728-740.
  71. Kato T, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S, Yoshikawa T. Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia. Mol Psychiatry 2005;10(11):1045-1055.
  72. Khaitovich P, Lockstone HE, Wayland MT, Tsang TM, Jayatilaka SD, Guo AJ, Zhou J, Somel M, Harris LW, Holmes E, Pääbo S, Bahn S. Metabolic changes in schizophrenia and human brain evolution. Genome Biol. 2008;9(8):R124.
  73. Kim AH, Reimers M, Maher B, Williamson V, McMichael O, McClay JL, van den Oord EJ, Riley BP, Kendler KS, Vladimirov VI. Micro RNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophr Res 2010;124(1-3):183–191.
  74. Kim S, Cho H, Lee D, Webster MJ. Association between SNPs and gene expression in multiple regions of the human brain. Transl Psychiatry 2012;2:e113.
  75. Kim S, Choi KH, Baykiz AF, Gershenfeld HK. Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex. BMC Genomics 2007;8:413.
  76. Kim S, Webster MJ. Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Mol Psychiatry 2011;16(4):452-461.
  77. Kim S, Hwang Y2 Lee D, Webster MJ. Transcriptome sequencing of the choroid plexus in schizophrenia. Transl Psychiatry. 2016 Nov; 6(11): e964
  78. Kim Y, Xia K, Tao R, Giusti-Rodriguez P, Vladimirov V, van den Oord E, Sullivan PF. A meta-analysis of gene expression quantitative trait loci in brain. Transl Psychiatry 2014;4:e459.
  79. Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Nilzato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. Hum Mol Genet 2009;18(13):2483-2494.
  80. Kohen R, Dobra A, Tracy JH, Haugen E. Transcriptome profiling of human hippocampus dentate gyrus granule cells in mental illness. Transl Psychiatry 2014;4:e366.
  81. Kubota-Sakashita M, Iwamoto K, Bundo M, Kato T. A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia. Mol Brain 2014;7:5.
  82. Lan MJ, McLoughlin GA, Griffin JL, Tsang TM, Huang JTJ, Yuan P, Manji H, Holmes E, Bahn S. Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder. Mol Psychiatry 2009;14:269-279.
  83. Lee BJ, Marchionni L, Andrews CE, Norris AL, Nucifora LG, Wu YC, Wright RA, Pevsner J, Ross CA, Margolis RL, Sawa A, Nucifora FC Jr. Analysis of differential gene expression mediated by clozapine in human postmortem brains. Schizophr Res 2017;185: 58-66.
  84. Lipska BK, Mitkus S, Caruso M, Hyde TM, Chen J, Vakkalanka R, Straub RE, Weinberger DR, Kleinman JE. RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity. Hum Mol Genet 2006;15(18):2804-2812.
  85. Liu C, Cheng L, Badner JA, Zhang D, Craig DW, Redman M, Gershon ES. Whole-genome association mapping of gene expression in the human prefrontal cortex. Mol Psychiatry 2010;15(8):779-784.
  86. Luo X, Mattheisen M, Li M, et al. Systematic integration of brain eQTL and GWAS Identifies ZNF323 as a novel schizophrenia risk gene and suggests recent positive selection based on compensatory advantage on pulmonary function. Schizophr Bull 2015;41(6):1294-1308.
  87. Mei J, Kolbin D, Kao HT, Porton B. Protein expression profiling of postmortem brain in schizophrenia. Schizophr Res 2006;84(2-3):204–213.
  88. Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, Wang SC, Petronis A. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 2008;82(3):696-711.
  89. Mistry M, Gillis J, Pavlidis P. Genome-wide expression profiling of schizophrenia using a large combined cohort. Mol Psychiatry 2013;18(2):215-225.
  90. Moreau MP, Bruse SE, David-Rus R, Buyske S, Brzustowicz LM. Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder. Biol Psychiatry 2011;69(2):188-193.
  91. Ovadia G, Shifman S. The genetic variation of RELN Expression in schizophrenia and bipolar disorder. PLoS One 2011;6(5):e19955.
  92. Pennington K, Beasley CL, Dicker P, Fagan A, English J, Pariante CM, Wait R, Dunn MJ, Cotter DR. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry 2008;13(12):1102-1117.
  93. Perez-Santiago J, Diez-Alarcia R, Callado LF, Zhang JX, Chana G, White CH, Glatt SJ, Tsuang MT, Everall IP, Meana JJ, Woelk CH. A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia. J Psychiatr Res. 2012;46(11):1464-1474.
  94. Pillai A. Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expression. PLoS ONE 2008;3(3):e1784.
  95. Pinsonneault JK, Han DD, Burdick KE, Kataki M, Bertolino A, Malhotra AK, Gu HH, Sadee W. Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder. Neuropsychopharmacology 2011;36(8):1644-1655.
  96. Pinsonneault JK, Papp AC, Sadée W. Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors. Hum Mol Genet 2006;15(17):2636-2649.
  97. Pinsonneault JK, Frater JT, Kompa B, Mascarenhas R, Wang D, Sadee W. Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits  PLoS One. 2017; 12(6): e0179020.
  98. Porton B, Wetsel WC. Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia. Schizophr Res 2007;94(1-3):366-370.
  99. Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry 2004;9(7):684-697.
  100. Roig B, Moyano S, Martorell L, Costas J, Vilella E. The discoidin domain receptor 1 gene has a functional A2RE sequence. J Neurochem 2012;120(3):408-418.
  101. Rueckert EH, Barker D, Ruderfer D, Bergen SE, O’Dushlaine C, Luce CJ, Sheridan SD, Theriault KM, Chambert K, Moran J, Purcell SM, Madison JM, Haggarty SJ, Sklar P. Cis-acting regulation of brain specific ANK3 gene expression by a genetic variant associated with bipolar disorder. Mol Psychiatry 2013;18(8):922-929.
  102. Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S. Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Mol Psychiatry 2006;11(10):965-978.
  103. Sabunciyan S, Kirches E, Krause G, Bogerts B, Mawrin C, Llenos IC, Weis S. Quantification of total mitochondrial DNA and mitochondrial common deletion in the frontal cortex of patients with schizophrenia and bipolar disorder. J Neural Transm 2007;114(5):665-674.
  104. Sartorius LJ, Weinberger DR, Hyde TM, Harrison PJ, Kleinman JE, Lipska BK. Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP. Neuropsychopharmacology 2008;33(11):2626-2634.
  105. Schubert KO, Föcking M, Cotter DR. Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: Potential roles in GABAergic interneuron pathology. Schizophr Res 2015;S0920-9964(15):00077-8.
  106. Schultz, CC, Nenadic I, Riley B. Vladimirov VI, Wagner G, Koch K, Schachtzabel C, Mühleisen TW, Basmanav B, Nöthen MM, Deufel T, Kiehntopf M, Rietschel M, Reichenbach JR, Cichon S, Schlösser RG, Sauer H. ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies. Schizophr Bull 2014;40(3):532-541.
  107. Scola G, Kim, HK, Young LT, Andreazza AC. A fresh look at complex I in microarray data: clues to understanding disease-specific mitochondrial alterations in bipolar disorder [letter]. Biol Psychiatry 2013;73(2):e4-e5.
  108. Seifuddin F, Pirooznia M, Judy J, Goes FS, Potash JB, Zandi PP. Systematic review of genome-wide gene expression studies of bipolar disorder. BMC Psychiatry 2013;13:213.
  109. Sekar A, Bialas AR, de Rivera H, et al. Schizophrenia risk from complex variation of complement component 4. Nature 2016;530(7589):177-83.
  110. Seredenina T, Sorce S, Herrmann FR, Ma Mulone XJ, Plastre O, Aguzzi A, Jaquet V, Krause KH. Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse. Transl Psychiatry. 2017 Aug; 7(8): e1206.
  111. Severance EG, Yolken RH. Lack of RIC-3 congruence with beta2 subunit-containing nicotinic acetylcholine receptors in bipolar disorder. Neuroscience 2007;148(2):454-460.
  112. Severance EG, Yolken RH. Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia. Genes Brain Behav 2008;7(1):37-45.
  113. Shao L, Vawter MP. Shared gene expression alterations in schizophrenia and bipolar disorder. Biol Psychiatry 2008;64(2):89-97.
  114. Silberberg G, Ben-Shachar D, Navon R. Genetic analysis of nitric oxide synthase 1 variants in schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2010;153B(7):1318-1328.
  115. Silberberg G, Lundin D, Navon R, Ohman M. Deregulation of the A-to-I RNA editing mechanism in psychiatric disorders. Hum Mol Genet 2012;21(2):311-321.
  116. Sinclair D, Fillman SG, Webster MJ, Weickert CS. Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness. Sci Rep 2013;3:3539.
  117. Sinclair D, Fullerton JM, Webster MJ, Weickert CS. Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants. PLoS ONE 2012;7(3):e31720.
  118. Sinclair D, Webster MJ, Fullerton JM, Weickert CS. Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder. BMC Psychiatry 2012;12:84.
  119. Slonimsky A, Levy I, Kohn Y, Rigbi A, Ben-Asher E, Lancet D, Agam G, Lerer B. Lymphoblast and brain expression of AHI1 and the novel primate-specific gene, Cforf217, in schizophrenia and bipolar disorder. Schizophr Res 2010;120(1-3):159-166.
  120. Stazisar M, Cammaerts S, van der Ven K, Forero DA, Lenaerts AS, Nordin A, Almeida-Souza L, Genovese G, Timmerman V, Liekens A, De Rijk P, Adolfsson R, Callaerts P, Del-Favero J. MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets. Mol Psychiatry 2015;20(4);472-481.
  121. Struyf J, Dobrin S, Page D. Combining gene expression, demographic and clinical data in modeling disease: a case study of bipolar disorder and schizophrenia. BMC Genomics 2008; 9:531.
  122. Sun X, Wang JF, Tseng M, Young LT. Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. J Psychiatry Neurosci 2006;31(3):189-196.
  123. Tao R, Cousjin H, Jaffe AE, Burnet PWJ, Edwards F, Eastwood SL, Shin JH, Lane TA, Walker MA, Maher BJ, Weinberger DR, Harrison PJ, Hyde TM, Kleinman JE. Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. JAMA Psychiatry 2014;71(10):1112-1120.
  124. Tan ML, Dyck BA, Gabriele J, Daya RP, Thomas N, Sookram C, Basu D, Ferro MA, Chong VZ, Mishra RK. Synapsin II gene expression in the dorsolateral prefrontal cortex of brain specimens from patients with schizophrenia and bipolar disorder: effect of lifetime intake of antipsychotic drugs. Pharmacogenomics J 2014;14(1):63-69.
  125. Thiselton DL, Vladimirov VI, Kuo P-H, McClay J, Wormley B, Fanous A, O’Neill FA, Walsh D, Van den Oord EJCG, Kendler KS, Riley BP. AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biol Psychiatry 2008;63(5):449-457.
  126. Uezato A, Yamamoto N, Iwayama Y, et al. Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. Transl Psychiatry. 2015. doi: 10.1038/tp.2015.154.
  127. Umeda-Yano S, Hashimoto R, Yamamori H. Expression analysis of the genes identifies in GWAS of the post mortem brain tissues from patients with schizophrenia. Neurosci Lett 2014;568:12-16.
  128. va den Oord EJCG, Clark SL, Xie LY, et al. A whole methylome Cp G-SNP association study of psychosis in blood and brain tissue. Schizophr Bull. 2015. doi: 10.1093/schbul/sbv182.
  129. Vila-Rodriguez F, Honer WG, Innis SM, Wellington CL, Beasley CL. ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotype. J Psychiatry Neurosci 2011;36(1):47-55.
  130. Weis S, Llenos IC, Dulay JR, Elashoff M, Martinez-Murillo F, Miller CL. Quality control for microarray analysis of human brain samples: the impact of postmortem factors, RNA characteristics, and histopathology. J Neurosci Methods 2007;165(2):198-209.
  131. Weissleder C, Fung SJ, Wong MW, Barry G, Double KL, Halliday GM, Webster MJ, Weickert CS. Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts. Front Aging Neurosci. 2016; 8: 274.
  132. Wendland JR. Increased gene expression of diacylglycerol kinase eta in bipolar disorder. Int J Neuropsychopharmacology 2010; 13: 1127-1128.
  133. Williamson VS, Mamdani M, McMichael GO, Kim AH, Lee D, Bacanu S, Vladimirov VI. Expression quantitative trait loci (eQTLs) in microRNA genes are enriched for schizophrenia and bipolar disorder association signals. Psychol Med 2015; 45 (12): 2557-2569.
  134. Wilson GM, Flibotte S, Chopra V, Melnyk BL, Honer WG, Holt RA. DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling. Hum Mol Genet 2006;15(5):743-749.
  135. Wong AHC, Likhodi O, Trakalo J, Yusuf M, Sinha A, Pato CN, Pato MT, Van Tol HHM, Kennedy JL. Genetics and transcription of 14-3-3 isoforms in schizophrenia and bipolar disorder. Schizophr Res 2005;78(2-3):137-146.
  136. Wong J, Rothmond DA, Webster MJ, Weickert CS. Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia. Schizophr Bull 2013;39(1):130-140.
  137. Xu B, Wratten N, Charych EI, Buyske S, Firestein BL, Brzustowicz LM. Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. PLoS Med 2005;2(10):e263.
  138. Yano-Umeda S, Hashimoto R, Yamamori H, Weickert CS, Yasuda Y, Ohi K, Fujimoto M, Ito A, Takeda M. Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia. Neurosci Lett. 2014;568:12-16.
  139. Zhan L, Kerr JR, Lafuente MJ, Maclean A, Chibalina MV, Liu B, Burke B, Bevan S, Nasir J.. Altered expression and coregulation of dopamine signaling genes in schizophrenia and bipolar disorder. Neuropathol Appl Neurobio 2011;37(2):206-219.
  140. Zhang L, Su TP, Choi K, Webster M, Li CT, Chung MY, Chen YS, Bai YM, Chou YH, Barker JL, Barrett JE, Li XX, Li H, Benedek DM, Ursano R. P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. J Psychiatr Res 2011;45(4):435-441.
  141. Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee ML, Xiao T, Papp A, Wang D, Sadée W. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci U S A 2007;104(51):20552-20557.
  142. Zhao Z, Webb BT, Jia P, Bigdeli TB, Maher BS, van den Oord E, Bergen SE, Amdur RL, O’Neill FA, Walsh D, Thiselton DL, Chen X, Pato CN; International Schizophrenia Consortium, Riley BP, Kendler KS, Fanous AH. Association study of 167 candidate genes for schizophrenia selected by a multi-domain evidence-based prioritization algorithm and neurodevelopmental hypothesis. PLoS One 2013;8(7):e67776.
  143. Zhao Z, Xu J, Chen J, Kim S, Reimers M, Bacanu SA, Yu H, Liu C, Sun J, Wang Q, Jia P, Xu F, Zhang Y, Kendler KS, Peng Z, Chen X. Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. Mol Psychiatry 2014;20(5):563-572.
  144. Zhu Y, Kalbfleisch T, Brennan MD, Li Y. A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene. Schizophr Res 2009;109(1-3):86-89.
  145. Gagliano SA, Ptak C, Mak DY, Shamsi M, Oh G, Knight J, Boutros PC, Petronis A. Allele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS Am J Hum Genet 2016; 98 (5): 956-62.
  146. Prusty BK, Gulve N, Govind S, et al. Active HHV-6 infection of cerebellar Purkinje cells in Mood Disorders. Frontiers in Microbiology. 2018.  doi: 10.3389/fmicb.2018.01955.
  147. Webster MJ, Kim S. Collecting, storing, and mining research data in a brain bank. Handb Clin Neurol 2018: 150: 167-179.
  148. Hagihara H, Catts VS, Katayama Y, et al. Decreased brain pH as a shared endophenotype of psychiatric disorders. Neuropsychopharmacology. 2018; 43: 459-468.
  149. Fillman SG, Sinclair D, Fung SJ, et al. Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder. Transl Psychiatry. 2014. 4, e365; doi:10.1038/tp.2014.8.