Awarded Trial: 99-128
Mean dose = 1.7 mg/day
Secondary Drug Intervention
Duration of Study Period for Each Subject
Twenty-two patients with bipolar depression received the anti-parkison?s drug pramipexole or placebo. Sixty-seven percent of patients receiving the drug had a 50% reduction in symptoms, whereas only 20% of patients receiving placebo improved to a similar degree.
Goldberg JF, Burdick KE, Endick CJ. Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depression. American Journal of Psychiatry 2004;161:564-566.
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Cornell University Medical College
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