Awarded Trial: 98-RC-305-4
Secondary Drug Intervention
Duration of Study Period for Each Subject
Patients with acute mania received oxcarbazepine for 14 days, no drug for 7 days, and oxcarbazepine again for 14 days. Four of 12 patients experienced a 50% reduction in YMRS scores. Six patients withdrew prematurely from the trial due to side effects or lack of efficacy.
Hummel B, Walden J, Stampfer R, Dittmann S, Amann B, Sterr A, Schaefer M, Frye MA, Grunze H. Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on-off-on design. Bipolar Disorder 2002;4:412-417.
University of Frieburg
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