Awarded Trial: 98-RC-301-7
Bipolar disorder and recurrent major depression with history of substance abuse
Secondary Drug Intervention
Duration of Study Period for Each Subject
The pregnenolone group showed trends toward greater improvement, relative to placebo, on the HRSD and YMRS. A post hoc analysis of completers found a statistically significant reduction in HRSD scores with pregnenolone as compared to placebo. Pregnenolone appeared to be safe and well tolerated. Findings suggest that pregnenolone use may be associated with some improvement in manic and depressive symptoms but not cognition in depressed patients with a history of substance use.
Osuji IJ, Vera-Bolanos E, Carmody TJ, Brown ES. Pregnenolone for cognition and mood in dual diagnosis patients. Psychiatry Research 2010;178:309-312.
E. Sherwood Brown
University of Texas Southwestern Medical Center at Dallas
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