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Awarded Trial: 10T-001

Grant ID

10T-001

Illness

Bipolar

Primary Drug/Intervention

Allopurinol

Primary Dosage

300 mg (2x per day)

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Weiser

Sample Size

180

Duration of Study Period for Each Subject

18 months

Outcome Measurements

N/A

Results

180 patients with acute mania, mean young mania rating score (YMRS)=25, were randomized to drug (n=90) or placebo (n=90); 82% completed the 6-wk study. At the end of the 6-wk trial, subjects on the drug improved by 10.8 YMRS points, and subjects on placebo improved by 11.3 YMRS points, with no difference between the groups, p=0.69. No significant side effects were reported. We conclude that allopurinol is not an effective treatment for acute mania.

Publication

Being submitted.

Link

N/A

PI Name

Mark Weiser

Degree

MD

Center

Psychiatric Outpatient Clinic

Institution

Sheba Medical Center

Address

Sheba Medical Center

City or Town

Tel-Hashomer

State or Province

N/A

Zip or Postal Code

52621

Country

Israel

Email Address

m.weiser@netvision.net.il