Awarded Trial: 07TGS-1022
Secondary Drug Intervention
7000-10000 lux for 7.5 to 45 minutes
Duration of Study Period for Each Subject
CGI, HAM-D, YMRS
Forty-four (44) patients with BP depression were randomized to light therapy (n=18), low-output negative ion generator (n=20), and high-output negative ion generator (n=6) for 8 weeks. During that time, they were maintained on a stable dose of psychotropic medication. There were no significant differences between the groups in outcome, although the number tested in the third group was too small to be statistically significant.
Dauphinais DR, Rosenthal JZ, Terman M, DiFebo HM, Tuggle C, Rosenthal NE. Controlled trial of safety and efficacy of bright light therapy vs. negative air ions in patients with bipolar depression. Psychiatry Res. 2012 Mar 30;196(1):57-61.
Capital Mood Disorders Foundation
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